Volume 35, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Past attempts to immunize mice against a fatal infection utilizing related hemoflagellates have been unsuccessful. In the present study, C57BL/6 mice received a footpad inoculation of 10 promastigotes of . Six and 9 weeks subsequent to this inoculation mice were infected intraperitoneally with the Tulahuen strain of . All immunized mice survived infection over the 6-month period of observation whereas control mice regularly died. There was an early transient parasitemia in the immunized mice. Culture of blood and organs as well as histopathological examination of various organs 6 months post-challenge failed to yield any evidence of . Heat-killed and freeze-thawed extracts of promastigotes did not confer any protection. These observations raise the possibility that certain leishmanial species might confer natural protection against a infection and that this information could be useful in the development of a vaccine.


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  • Accepted : 28 Apr 1986

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