Volume 35, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



An indirect immunofluorescence (IIF) test was performed with human sera to detect cross-reactivity of antibodies with other species of parasites, with other blood and tissue parasites, and with various tick-borne organisms. Antisera to cross reacted with other species, but at lower dilutions than with the homologous antigens, and occurred most often during the acute phase of the disease. Cross-reactions with antibodies to malaria, Colorado tick fever, and a variety of other parasitic diseases were uncommon. However, acute and convalescent phase sera from 4 patients with suspected or confirmed Rocky Mountain spotted fever showed a rise in titer to antigen. In addition, 6 of 185 serum samples from children on an Indian reservation in North Carolina had IIF titers of ≥1:256, suggesting a possible focus of infections in humans.


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