1921
Volume 35, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Administration of cyclosporin A (CyA) to mice prior to infection and at weekly intervals during the infection with resulted in an increase in cyst output and a delay of the elimination phase of the infection. A short term treatment (4 days) of infected mice with CyA induced a significantly higher cyst release after treatment. CyA did not affect the ability of immune mice to resist reinfection. Our findings indicate that CyA has compromised immunological control of the primary infection, but not the ability of the immune host to resist reinfection. We propose that the use of immunosuppressive drugs may be a contributing factor in transmission of giardiasis.

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/content/journals/10.4269/ajtmh.1986.35.496
1986-05-01
2017-09-19
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1986.35.496
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  • Accepted : 04 Dec 1985

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