Volume 34, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A purified glycoprotein, glycoprotein-2, which was isolated from soluble egg antigen, was tested in an enzyme-linked immunoadsorbent assay for its potential as an immunodiagnostic reagent. Using empirically-derived criteria of endpoint titer, 39/40 sera from -infected individuals were scored correctly as positive in a blind test. Of these, 26/40 were from individuals who excreted fewer than 100 eggs per gram of stool. No cross reactions were observed with sera from uninfected individuals (0/20) or from individuals infected with (0/22), (0/6) or (0/4). Cross reactions were observed with 3/24 individuals infected with who excreted >2,000 eggs per 10 ml urine. Glycoprotein-2 appears to satisfy the requisite criteria of specificity and sensitivity to warrant further evaluation.


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