Volume 34, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The in vivo and in vitro effects of cyclosporin A on were examined. Mice receiving 150 or 75 mg/kg/day of cyclosporin A and infected with 48 hr later had significantly higher parasitemias and earlier mortality than controls. Mice receiving cyclosporin A after infection had parasitemias similar to controls. Infections with both the reticulotropic Y and the miotropic CL strains of were enhanced by cyclosporin A. The in vitro replication of epimastigotes, but not the intracellular replication of amastigotes, in mouse macrophages was inhibited by 5 µg cyclosporin A/ml. Enhancement of the infection by cyclosporin A was not due to an effect of macrophages since the drug did not prevent development of activated macrophages capable of killing intracellular .


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