Volume 34, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



An American Peace Corps volunteer contracted chloroquine-resistant malaria while serving in Malawi and taking regular chloroquine prophylaxis. Resistance was confirmed by in vitro testing of his parasites for chloroquine and pyrimethamine. The possibility of Fansidar®-resistant falciparum malaria was also suggested in this case. American expatriates residing in or traveling to Malawi are advised to either take both chloroquine and Fansidar®, or alternatively amodiaquine or doxycycline alone. Any breakthrough of slide-proven falciparum malaria in these individuals should be seriously suspected to be chloroquine- and Fansidar®-resistant malaria, and should be treated with quinine and tetracycline.


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