Volume 34, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Susceptibility to infection, resulting viremia and antibody responses, and potential to provide infectious blood meals for were determined and compared for the red fox (), raccoon (), and opossum () exposed to La Crosse (LAC) virus transmitted by mosquitoes, . Woodchucks () were infected with LAC virus by needle and syringe. All 5 red foxes became viremic following the bite of a single LAC virus-infected female . Maximum viremia titers were at or above the threshold of infection for in 4 of 5 red foxes for 1–3 days. Biological transmission of LAC virus from infected red foxes to chipmunks () was accomplished by . Neutralizing antibody titers in red foxes peaked between day 13 and 27 and were still detectable 3 months post-infection. Woodchucks appear to be efficient amplifiers of LAC virus. Three of 4 inoculated woodchucks became viremic. Maximum viremia titers were consistently above the experimentally determined threshold of infection for . Raccoons and opossums were not as susceptible to LAC virus infection as were red foxes or woodchucks. Only 1 of 5 raccoons became viremic. The viremia titer was low and was detected on only 1 day. Four of 5 raccoons developed LAC virus-neutralizing antibody titers, however. None of the opossums became viremic and only 2 developed LAC virus-neutralizing antibody titers.


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