1921
Volume 34, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

High neutrophil and eosinophil chemotactic activities of soluble extract of cercariae (SjCe-ext) were detected in vitro by using blind-well chemotaxis chambers and Millipore filters in a dose-dependent manner. Low doses (total of 0.25 and 2.5 µg) of SjCe-ext induced significant neutrophilic infiltrations in normal and -infected (8 week) guinea pig tissues beginning at 2 hr after the intradermal injection. Eosinophilic responses were observed in the infected animals especially in early phase (2–8 hr post-injection of SjCe-ext). SjCe-ext elicited strong immediate skin reactions (at 30 min) in the infected guinea pigs. Possible roles of these chemotactic activities and hypersensitivity reaction in infection are discussed.

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/content/journals/10.4269/ajtmh.1985.34.513
1985-05-01
2017-09-24
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1985.34.513
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  • Accepted : 29 Dec 1984

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