Volume 34, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Parasitologic, hematologic, and immunologic parameters were monitored in intact (nonsplenectomized), adult chimpanzees infected with a “chimp-adapted” strain of . Following primary and secondary injections of 10 -infected erythrocytes, each chimpanzee developed a low grade parasitemia (up to 1,000/mm) and maintained the infection without evidence of eliminating the parasites. Hematologic and serum biochemical values, as well as the majority of immunologic parameters tested, remained unaltered in infected chimpanzees. However, 2 weeks after infection T cells from infected chimpanzees demonstrated an enhanced response in vitro to stimulation with the mitogen PHA, and monocyte phagocytic activity for antibody-coated erythrocytes (Fc-mediated phagocytosis) increased significantly. During malarial infection, apes developed a strong T cell proliferative response to antigens and monocytes showed enhanced phagocytic activity for -infected erythrocytes in the absence of immune serum. These results suggest that cellular immune mechanisms, especially macrophage activation, may help control, but not eliminate, malaria in chimpanzees.


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