1921
Volume 34, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Artificial selection on strains of showing susceptibility and refractoriness to oral infection with yellow fever virus (YFV) suggests that there is a significant genetic component to this trait. Using a population with an average susceptibility of 15%, inbreeding of isofemale lines followed by individual selection produced susceptible (29% infected) and refractory (11% infected) lines. The difference between lines was largely apparent before individual selection, which failed to increase/decrease susceptibility significantly. The findings suggest that very few loci with a major bearing on the trait segregated genetic variation in the original population sample, and that non-genetic factors also play a major role in determining whether or not females become infected with YFV.

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/content/journals/10.4269/ajtmh.1985.34.1225
1985-11-01
2017-09-26
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1985.34.1225
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  • Accepted : 18 Jun 1985

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