1921
Volume 34, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The paradox of schistosomiasis is that infection confers immunity to its host, yet immunization with subcellular antigens of the parasite does not, in general, induce protective immunity. Infection or immunization with subcellular antigens of confers high levels of immunity to a challenge infection with another trematode, . We have isolated by antibody affinity chromatography a cross-reactive antigen, designated Fh, and also have shown that this antigen confers immunity in mice to a challenge infection with . This antigen was compared with a crude worm extract (FhWWE) as to its ability to induce an IgG antibody response in mice, and to determine whether it had a protective effect in mice to a challenge infection with metacercariae. Mice immunized with Fh or FhWWE, and subsequently infected with , developed higher IgG antibody levels to Fh, as measured by ELISA, than -infected controls. Mice immunized with FhWWE did not develop significant levels of resistance to challenge with metacercariae. Mice immunized with Fh and infected with metacercariae developed 69%–78% less worms than controls. An cross-reactive, cross-protective defined immunity antigen confers in mice significant levels of protection to a challenge infection with .

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/content/journals/10.4269/ajtmh.1985.34.1127
1985-11-01
2017-11-24
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1985.34.1127
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  • Accepted : 16 Apr 1985

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