Volume 33, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The kinetics of peripheral blood basophil and eosinophil responses in guinea pigs to multiple infestation by nymphal and adult (vessel feeder) and adult (pool feeder) were examined. Hosts exhibited significant blood basophil and eosinophil responses to feeding by both arthropods. Basophilia was slow to develop and mild in intensity following primary infestation but exhibited immediate anamnestic-type responses to secondary infestation, with marked but delayed-type responses to tertiary infestation. Basophilia developed quickly in guinea pigs infested with , and this response remained fairly consistent throughout the three infestation periods. Eosinophils did not respond to primary infestation but exhibited marked immediate responses to both secondary and tertiary infestations. -infested hosts exhibited marked eosinophilia in response to all infestations. Eosinophil levels returned to control levels 10 days post-tertiary infestation in hosts, whereas hosts exhibited normal eosinophil levels within 3–4 days after peak response. This study demonstrates that hosts respond to fast-feeding hematophagous arthropods with a peripheral blood basophilia and eosinophilia, as reported for slow-feeding (ticks) hematophagous arthropods. The difference in feeding strategy, whether vessel or pool feeder, appears to be reflected by differences in host blood leukocyte kinetics in response to parasitization by specific arthropods.


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