1921
Volume 33, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The congenitally athymic nude (nu/nu) mouse was studied as a model for amebic liver disease, using . Despite intrahepatic inoculation of massive numbers of amebae, we could not produce sustained infections in nu/nu mice. We also failed to induce hepatic amebiasis in thymus-intact nu/+ and +/+ littermates, or in nu/+ mice pretreated with rabbit antimouse thymocyte globulin. Humoral response was measured in both the nu/nu and nu/+ mice. Nu/+ but not nu/nu animals developed a specific IgG response after challenge with . There were no significant IgM responses. Pretreatment with silica increased susceptibility of both nu/nu and nu/+ mice to development of liver abscesses. These studies suggest that host resistance in murine amebiasis is critically dependent upon the macrophage, but not upon T cell-mediated defenses.

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/content/journals/10.4269/ajtmh.1984.33.372
1984-05-01
2017-11-20
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1984.33.372
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  • Accepted : 10 Nov 1983

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