Volume 33, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Twenty-six Laotian refugees infected with or liver flukes, and 15 uninfected controls, were assessed clinically by history, physical examination, serum 5′nucleotidase level, and serum immunoglobulin E level. Ultrasound studies of the biliary tract were also done on a subset of six infected subjects. The results showed no differences between subjects and controls with respect to clinical symptoms, physical findings, 5′nucleotidase, or biliary ultrasound. Mean serum IgE levels were four times higher in fluke-infected individuals than uninfected controls ( < 0.002). Even when those infected with other parasites in addition to were excluded from the analysis, serum IgE levels remained three times higher in fluke infected individuals ( = 0.06). This study provides some evidence that the fluke provokes a mild immune response in the asymptomatic human host but may not require eradication.


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