1921
Volume 33, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The ability of dengue viral antigen(s) from different sources, and preformed antigen-antibody complexes, to activate the third component of human complement (C3) in vitro was demonstrated by using split products of human C3. Dengue type 2 viral antigen(s) from suckling mouse brain and from infected monocytes activated C3 via the alternative pathway, while preformed soluble dengue-2 antibody complex activated mainly the classical pathway. The implications of this finding for the pathogenesis of dengue hemorrhagic fever are discussed.

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/content/journals/10.4269/ajtmh.1984.33.1239
1984-11-01
2018-12-11
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1984.33.1239
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  • Accepted : 06 Apr 1984

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