1921
Volume 33, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Autologous mixed lymphocyte reactions (AMLR) were studied in 18 individuals chronically infected with . These individuals were further classified into three clinical groups: the asymptomatic indeterminate form (n = 5); the mega disease form (n = 5); and the cardiomyopathy form (n = 8). While patients with mega disease showed a normal proliferative response when compared with normal controls, the indeterminate group showed a lowered response in sharp contrast with the heart disease group, which presented a very high proliferative response to autologous non-T cells. These abnormal AMLR represent direct evidence for an immunoregulatory malfunction which may be involved in the inflammatory cardiac damage in chronic Chagas' disease.

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/content/journals/10.4269/ajtmh.1984.33.1078
1984-11-01
2019-01-22
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1984.33.1078
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  • Accepted : 01 Jun 1984

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