1921
Volume 32, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Albendazole, a new anthelmintic drug was evaluated in Malaysia in 91 patients, with single or mixed infections of , and hookworm. Albendazole was administered as a single dose of 400 mg, 600 mg, or 800 mg. The cure rate for at all three doses was 100% at days 14 and 21 post-treatment; for hookworm it was 98.8%, 100% and 98%, respectively, at day 14 and 68.8%, 100% and 84%, respectively, at day 21; for it was 31.2%, 57.1% and 42.3%, respectively, at day 14 and 27.3%, 60.9% and 48.0%, respectively, at day 21. The egg reduction rate at day 21 was 100% at all three doses for , 94.5%, 100% and 96.1%, respectively, for hookworm; and 39.2%, 85.1% and 72.8%, respectively, for . There were no side effects, and biochemical examination of blood and urine did not indicate any unfavourable changes. Based on this trial, the recommended dosage for and hookworm is a 400 mg single dose, and for is a 600 mg single dose. Albendazole appears to be more effective than other available anthelmintic drugs.

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/content/journals/10.4269/ajtmh.1983.32.984
1983-09-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1983.32.984
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  • Accepted : 21 Oct 1982

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