1921
Volume 32, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

C3HeB/FeJ peritoneal exudate macrophages elicited with a variety of sterile inflammatory agents or with strain BCG were exposed to amastigotes in vitro. The percentages of -infected macrophages were similar in resident and inflammatory macrophage populations over 72 hours in culture. Inflammatory macrophages supported intracellular replication of in excess of that by resident macrophages. These macrophages also failed to demonstrate cytotoxicity to tumor cells in vitro, a defined nonspecific effector function of activated macrophages. However, macrophages from BCG-treated mice were significantly more resistant to initial infection with , killed intracellular amastigotes by 72 hours in culture and were cytotoxic to tumor cells, indicating full immunologic activation. The inability of inflammatory macrophages to kill parasites suggests that inflammation may actually contribute to the pathogenesis of leishmaniasis.

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/content/journals/10.4269/ajtmh.1983.32.952
1983-09-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1983.32.952
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  • Accepted : 28 Jan 1983

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