Volume 32, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Experimental infection of 11 and sloths with St. Louis encephalitis (SLE) virus produced detectable viremias of seven to 27 (median 13) days duration and maximum titers of 2.7 to 6.5 (median 5.1) log median suckling mouse intracranial lethal doses (SMicLD) per ml. Experimental SLE viremia onset was delayed and maximum titer depressed in two sloths concurrently infected with naturally acquired viruses. SLE viremias in four experimentally inoculated cormorants were shoter, and of equal or lower titer, than in sloths. Colonized mosquitoes were infected by feeding on sloths circulating at least 4.8 log SMicLD of SLE virus per ml, and subsequently transmitted the infection to mice and chicks. An uninoculated baby became infected by contact transmission from its mother. The antibody response of sloths to SLE virus was slow, being undetectable until several weeks post-inoculation. However, both sloth species developed high and long-lasting neutralizing and hemagglutination-inhibition antibody titers. The complement-fixation antibody response in was lower and slower to develop than in . Sloths with naturally acquired SLE virus antibody did not become detectably viremic after experimental inoculation. Neither sloths nor cormorants become overtly ill from SLE virus infection.


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