Volume 32, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Significant chemotactic activity for eosinophils was detected in soluble egg antigen (SEA) preparations of both and in dose-dependent fashion. The activity of SEA was higher than that of SEA. Gel filtration on Sephadex G-150 showed that SEA was composed of two groups of eosinophil chemotactic factors (ECFs), one of high molecular weight (JEE-H) and the other of low molecular weight (JEE-L). SEA showed ECF composition similar to that of SEA. JEE-H was stable on heating (100°C, 60 min) and resistant to pronase digestion, but was sensitive to periodate oxidation. JEE-L was also stable on heating and resistant to pronase and carboxypeptidase A digestions. These properties of the ECFs were also held in common with those of SEA. JEE-L was extractable by toluene, indicating a hydrophobic nature. These results suggest that schistosome eggs themselves contain ECFs, and that the composition of and SEA-derived ECFs is essentially the same. However, they differ from the other ECFs which have already been described in schistosome infections.


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