Volume 32, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Infection of mouse peritoneal macrophages in vitro was used to examine the effect of elevated temperature on the intracellular replication of various strains of . Of eight cutaneous strains examined, all grew optimally at 35°C. At 37°C the reduction in growth was most pronounced for the New World cutaneous strains, and at 39°C three of four New World cutaneous strains were completely destroyed whereas all of the strains survived and exhibited at least 100% growth after 3 days. The results of these in vitro studies correlate closely with the outcome of heat therapy on two patients with cutaneous disease, suggesting that, in general, cutaneous lesions due to strains might be less responsive to heat therapy than lesions due to and related strains.


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  • Accepted : 26 Jul 1982

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