1921
Volume 32, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Single doses of 100 mg, 200 mg, 400 mg, and 600 mg of mebendazole in the treatment of very light to heavy infections all reduced egg output by over 80%. The egg reduction rates were not affected by increased dosages of mebendazole given in heavier infections. Lower cure rates were obtained in patients with heavier worm burdens despite increased dosages of mebendazole, probably as a result of the diarrhea which is frequently associated with heavy infection. A single dose of 600 mg mebendazole in the treatment of very light to very heavy infections gave egg reduction and cure rates similar to those obtained with the recommended multiple-dose regime of 100 mg mebendazole twice a day for 3 consecutive days. The single-dose treatment of infections with mebendazole is of considerable public health importance as this single dose regime is easy to administer, well-accepted, well tolerated, less expensive, and has a broad spectrum effect. The risk of erratic migration of with single doses of mebendazole does not appear to exceed the risk in a multiple-dose regime.

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/content/journals/10.4269/ajtmh.1983.32.118
1983-01-01
2017-11-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1983.32.118
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  • Accepted : 05 May 1982

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