1921
Volume 32, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The sensitivities and specificities of the indirect microimmunofluorescent antibody (IFA) and Weil-Felix (OXK) tests for scrub typhus were established for a range of titers using groups of diseased and control (other febrile illnesses) patients diagnosed by other methods. At a cut-off point of ⩾1:400, the IFA test was 0.96 specific, and at ⩾1:320, the OXK was 0.97 specific. Using either these highly specific levels of antibody or other rigorous diagnostic criteria (isolation or 4-fold rising titers), the prevalence of scrub typhus infection was determined to be 0.22 in an unselected population of febrile patients in a rural Malaysian hospital. Probability values (Pr) for the correct diagnosis of scrub typhus were then calculated from the specificity, sensitivity and prevalence determination for a range of titers. The Pr for an OXK titer of ⩾1:320 was 0.79, and the Pr for an IFA titer of ⩾1:400 was 0.78. When both these titers were present in a single specimen, the Pr increased to 0.96.

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/content/journals/10.4269/ajtmh.1983.32.1101
1983-09-01
2017-11-20
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1983.32.1101
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  • Accepted : 12 Jan 1983

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