Volume 32, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The antischistosomal activity of oral doses of amoscanate (4-isothiocyanato-4′-nitrodiphenylamine) was determined in infected (capuchin monkeys) and (rhesus monkeys). In infected with or an initial dose of 10 mg/kg body weight did not alter fecal egg counts, but a subsequent dose of 25 mg/kg markedly reduced both egg counts and worm burdens; in animals infected with , a single dose of 25 mg/kg of amoscanate was similarly effective. Comparable schistosomicidal effects were also produced in - and -infected by single oral doses of 20 and 35 mg/kg, respectively. In both and the coadministration of single oral doses of 50 or 75 mg/kg of erythromycin attenuated the appearance of mutagenic metabolites of amoscanate in the urine but did not interfere with the antischistosomal action of amoscanate. In non-infected monkeys single oral doses of 75 mg/kg of amoscanate with or without erythromycin (50 mg/kg in or 75 mg/kg in ) did not cause any major organ toxicity as revealed by gross and histopathologic examination, hematology, blood chemistry, electrocardiograms and urinalysis. The data indicate that in and , amoscanate is a relatively non-toxic antischistosomal agent effective orally against a broad spectrum of schistosome species.


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