1921
Volume 32, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

The antischistosomal activity of oral doses of amoscanate (4-isothiocyanato-4′-nitrodiphenylamine) was determined in infected (capuchin monkeys) and (rhesus monkeys). In infected with or an initial dose of 10 mg/kg body weight did not alter fecal egg counts, but a subsequent dose of 25 mg/kg markedly reduced both egg counts and worm burdens; in animals infected with , a single dose of 25 mg/kg of amoscanate was similarly effective. Comparable schistosomicidal effects were also produced in - and -infected by single oral doses of 20 and 35 mg/kg, respectively. In both and the coadministration of single oral doses of 50 or 75 mg/kg of erythromycin attenuated the appearance of mutagenic metabolites of amoscanate in the urine but did not interfere with the antischistosomal action of amoscanate. In non-infected monkeys single oral doses of 75 mg/kg of amoscanate with or without erythromycin (50 mg/kg in or 75 mg/kg in ) did not cause any major organ toxicity as revealed by gross and histopathologic examination, hematology, blood chemistry, electrocardiograms and urinalysis. The data indicate that in and , amoscanate is a relatively non-toxic antischistosomal agent effective orally against a broad spectrum of schistosome species.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1983.32.1055
1983-09-01
2017-11-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1983.32.1055
Loading
  • Accepted : 28 Jan 1983

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error