Abstract

Fansidar®, quinine, and combinations of the two were evaluated as therapy in 173 cases of falciparum malaria in Royal Thai Army soldiers. Falciparum malaria acquired in the area of the Thai-Khmer border, by military units under Fansidar prophylaxis, has proven refractory to Fansidar therapy. Concurrent use of a single drug as a routine chemoprophylactic and as first-line therapy appears to be inappropriate in this case. Feasible alternatives for either role, however, are not readily available.