Volume 31, Issue 3_Part_2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



This report summarizes the results of a longitudinal study of the characteristics of untreated infections with trophozoites and sporozoites of the , and strains of . The pre-initial-peak phases of infections with trophozoites of these strains were remarkably similar. These phases of sporozoite-induced infections were also similar except that infections with the and strains had a shorter incubation period and reached the initial peak more promptly than infections with the strain. The post-initial-peak phase of the primary attack in infections with the strain was significantly shorter than that phase of infections with either the or strain and was characterized by parasitemias of lesser intensity and fewer secondary peaks. The total duration of infections with trophozoites of either the or strain from onset of patency to self-cure was markedly shorter than the duration of infections with sporozoites of these strains. The duration of infections with sporozoites of the strain was significantly longer than the duration of infections with the strain. Monkey-to-monkey variations in the features of the post-initial-peak phase of infections, including the frequency of secondary attacks and the total duration of disease, were substantial. Although malaria morbidity was a common feature of primary attacks, the incidence of malaria deaths was low in infections with all three strains.


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