Volume 31, Issue 3_Part_2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The studies on infections with recorded in this Supplement had their origins in the World War II search for drugs that at well-tolerated doses would effect radical cure of naturally acquired infections with . At its onset, this search rested almost completely upon screening of new agents for activities against trophozoite-induced and sporozoite-induced infections with in chickens or in canaries and trophozoite-induced infections with in ducks. Compounds that exhibited promising activities in these systems, and appropriate levels of tolerability in rats, dogs, and rhesus monkeys, were evaluated in human volunteers for capacities to prevent or cure infections induced with sporozoites of . None of the agents selected on the basis of activities against the avian malarias exhibited such capabilities.


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