1921
Volume 31, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

A method was developed for quantitative localization of trophozoites in the small intestine of the mouse. Using this method, trophozoite distribution as a function of infecting dose of cysts, duration of infection, and mucosal histopathology was examined. Mice inoculated with 10 and 10 cysts were compared. The low dose group required longer to reach maximal levels of cyst excretion and trophozoite counts and had less marked histopathology. The groups were not different, however, in maximum rate of cyst excretion, maximum trophozoite count, and distribution of trophozoites and histopathology. The histopathological lesions were predominantly jejunal and transient, with beginning resolution despite continued presence of near maximal numbers of trophozoites on day 14. Early (day 4 and before) and late (day 90 and after) in the infection, cyst excretion was not a reliable indicator of the level of infection, since there were significant numbers of small bowel trophozoites in most animals without detectable cysts in the stool.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1982.31.60
1982-01-01
2017-09-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1982.31.60
Loading
  • Accepted : 24 Jun 1981

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error