Volume 31, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


. Hypnozoites of two strains of the human relapsing malaria parasite, , have been detected among maturing 7- and 10-day pre-erythrocytic schizonts in liver biopsies of chimpanzees infected by intravenous inoculation of sporozoites obtained from dissected salivary glands of heavily infected anopheline mosquitoes. As in the simian relapsing species, , the hypnozoites of at 7 and 10 days are uninucleate forms of approximately 4–5 µm diameter, lying within the cytoplasm of individual hepatocytes. Their presence in this relapsing human species is added support for the hypnozoite theory of malarial relapse.


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