Volume 31, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


To the Editor:

Dr. Campbell and his colleagues raise significant issues which we would like to clarify. Our research fulfilled the criteria for a “double-blind” study in that the investigators evaluating the patients and the patients themselves were unaware of the therapeutic regimens assigned. There were two different teams, one located in the “emergency room” tent who were responsible for the initial treatment given according to a randomized code. The second team, located in another tent, continued the management and follow-up. As for the patients, all were either stuporous or comatose and obviously not cognizant of their therapeutic regimens.

While it is true that 25% of the patients were “slide-negative,” the two deaths were in slide-positive patients. There were similar numbers of slide-negative patients in both groups, but in these patients the clinical diagnosis of malaria was based on strong evidence and the rapid response to quinine gave it further support.


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