1921
Volume 30, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The anthelmintic activity of Amoscanate (C 9333-GO/CGP 4540) has been studied in experimental infections with the human hookworm, , in hamsters; and natural infections with in mice; in mongrel dogs; and in rhesus monkeys. Single oral doses of 30–60 mg/kg eliminated 94 to 99% of the total parasites in 37-day-old non-patent infection, while single oral doses of 25 mg/kg expelled the entire worm burden in patent infection in hamsters. When incorporated in feed at the 0.01% level and administered ad lib. to hamsters at 20, 27 and 34 days postexposure for 5 days, the worm burdens were reduced 88 to 94%. was completely eradicated by a single oral dose of 200 mg/kg while and were expelled at doses of 12.6 mg/kg and 50 mg/kg, respectively. A dose of 25 mg/kg in dogs produced 100% fecal egg reduction in hookworm and 99% in ascarid infections. The drug at 3 × 2.5 mg/kg administered at 4-hour intervals produced similar effects in mixed and infections. Against natural infections of and in rhesus monkeys the drug showed 100% efficacy at a dosage of 60 mg/kg administered thrice at 12-hour intervals.

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/content/journals/10.4269/ajtmh.1981.30.992
1981-09-01
2017-11-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1981.30.992
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  • Accepted : 21 Feb 1981

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