1921
Volume 30, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

The anti-leishmanial activity of four imidazoles has been determined in -infected human monocyte-derived macrophage cultures. One of the imidazoles, hydrolyzed ketoconazole [-1-{4-[2-(2,4-dichlorophenyl)-2-(1-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxyphenyl}piperazine], eliminated 80 and 95% of the parasites at drug concentrations (2.0 and 2.5 µg/ml) that are achievable in vivo by a structurally similar compound, ketoconazole. These results demonstrate that an imidazole has anti-leishmanial activity in a model system, and suggests that hydrolyzed ketoconazole should be considered for in vivo trials in animal models of the disease.

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/content/journals/10.4269/ajtmh.1981.30.566
1981-05-01
2019-05-26
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1981.30.566
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  • Accepted : 13 Dec 1980

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