Volume 30, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The present work deals with the development of an improved animal model to study the association of salmonellosis and schistosomiasis. The animal chosen was the hamster, , which can be readily infected with . Normal hamsters and schistosome-infected hamsters (SIH) were given approximately 2.0 × 10 A intracardially. It was found that infections enhanced and prolonged the growth of A in hamsters. Animals with dual infections had increased mortality in comparison with those infected with just bacteria or parasite during the 50 days post-bacterial challenge. Further studies showed that in SIH, A persisted in various organs for up to 8 weeks post infection. In contrast, concurrent infections have no effect on A infections. Significant numbers of bacteria were cultured from well-washed schistosome worms recovered from SIH 6–8 weeks post-bacterial challenge. These findings suggest that a direct physical relationship between the bacteria and worms facilitates the establishment and growth of A in vivo, and that a deficit in host immune response is not a major factor involved in the enhanced growth of A.


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