Volume 30, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Sequentially collected sera from Mongolian jirds () infected with and were tested for antibodies to homologous and heterologous antigens by the enzyme-linked immunosorbent assay (ELISA). Titers were <1:100 prior to infection and rose rapidly (within 2 weeks). Peak titers were observed prior to patent microfilaremia, and high titers persisted during infection. Use of the homologous antigen did not increase sensitivity or specificity of the ELISA. In fact, -infected jirds demonstrated higher titers to the heterologous antigen, , than to the homologous antigen. Fractionation of antigen over a wide pH range using isoelectric focusing did not eliminate cross-reactions, but the reactions of 20 sera and 20 sera tested more strongly to specific fractions, particularly in the lower pH range.


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