Volume 30, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



One hundred and twenty-four small mammals of six species were inoculated with three strains of Colorado tick fever (CTF) virus to define viremia and neutralizing (N) antibody responses. Adult and , and juvenile and , were highly susceptible to development of viremic infection. Adult and were moderately susceptible (≥50% viremic). Five did not become viremic following experimental inoculation. was also relatively resistant (≤50% viremic). The longest duration of viremia (mean 15.8 days) and highest peak viremia levels (mean peak titer 10 plaqueforming units per ml) occurred in . Adult , juvenile , and juvenile had moderate viremias. Adult and often had short viremias during which virus was only intermittently detectable. N antibody production was most rapid in in comparison with other species. In addition, N antibody persisted for 1 year in this species. In other species, many animals lost detectable antibody 5–11 months after infection. No significant differences were found in patterns of infection between three CTF virus strains. We conclude that of the six species inoculated, is the best experimental host for CTF virus.


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