Volume 30, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Sera from Balb/c mice, hyperimmunized with ruptured epimastigotes of either or , lacked species-specificity when assayed for antibodies by indirect immunofluorescent microscopy and by the enzyme-linked immunosorbent assay. However, when plasma cells from those mice were fused with syngeneic mouse plasmacytoma cells, many of the resultant hybridomas synthesized antibodies which were species-specific. Four clones are synthesizing antibodies specific for antigens of . These antigens are associated with the cytoplasm, plasma membrane and flagellum. One clone is synthesizing a specific anti- antibody which appears to be reactive with the entire surface of the epimastigote. Another clone is reactive with a subpopulation of epimastigotes, thus suggesting some antigenic variability among cultured forms. Two clones are synthesizing antibody specific for antigens of , one of which is confined to the cytoplasm.


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  • Accepted : 28 Feb 1981

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