1921
Volume 30, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Sera from Balb/c mice, hyperimmunized with ruptured epimastigotes of either or , lacked species-specificity when assayed for antibodies by indirect immunofluorescent microscopy and by the enzyme-linked immunosorbent assay. However, when plasma cells from those mice were fused with syngeneic mouse plasmacytoma cells, many of the resultant hybridomas synthesized antibodies which were species-specific. Four clones are synthesizing antibodies specific for antigens of . These antigens are associated with the cytoplasm, plasma membrane and flagellum. One clone is synthesizing a specific anti- antibody which appears to be reactive with the entire surface of the epimastigote. Another clone is reactive with a subpopulation of epimastigotes, thus suggesting some antigenic variability among cultured forms. Two clones are synthesizing antibody specific for antigens of , one of which is confined to the cytoplasm.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1981.30.1192
1981-11-01
2017-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1981.30.1192
Loading
  • Accepted : 28 Feb 1981

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error