1921
Volume 30, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Immunological cross-reactivity between and insect trypanosomatids was demonstrated by immunofluorescence and confirmed by complement fixation, direct agglutination and cross-absorption experiments. As antigens, the following organisms were surveyed: and . Sera from patients with Chagas' disease or sera from rabbits immunized against various trypanosomatids were used as sources of antibodies. The demonstration of cross-reactivity was followed by a survey of 500 human sera (from normal persons or Chagas' disease patients) by immunofluorescence using insect trypanosomatids ( and ) as antigens. With 98.7% coincident positive results and 100% of coincident negative results were obtained. These findings may validate the use of insect trypanosomatids as an alternative source of antigen in the serodiagnosis of Chagas' disease by indirect immunofluorescence.

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/content/journals/10.4269/ajtmh.1981.30.1183
1981-11-01
2017-11-23
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1981.30.1183
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  • Accepted : 04 Apr 1981

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