Volume 29, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The nature of resistance to a primary infection with (Peabody strain) was studied in lethally irradiated, bone marrow- and/or thymocyte-reconstituted BALB/c mice. Mice depleted of T lymphocytes by thymectomy, lethal irradiation, and reconstitution with anti-theta serum-treated bone marrow cells developed significantly higher parasitemias than sham-thymectomized, lethally irradiated mice reconstituted with thymocytes alone. Natural resistance to could be partially restored to T lymphocyte-depleted mice by transfer of spleen cells depleted of B lymphocytes by treatment with anti-immunoglobulin serum. The greatest resistance to infection among lethally irradiated mice, however, was observed when T lymphocytes were given to mice with intact thymuses. The return of the spleen to normal size after enlargement resulting from infection with was shown to be a T cell-mediated response. Twenty days after peak parasitemia, the total cell and leucocyte numbers in the spleens of mice depleted of T lymphocytes were considerably higher than those of mice given T cells. A depression of humoral immune responsiveness to sheep red blood cells was also noted during primary infection, while cell-mediated immune responses remained near normal. Although the mechanism of parasite destruction was not determined, these results suggest that resistance to and recovery from a primary infection is modulated by T lymphocytes, and that depressed B cell function and normal T cell function are correlates of this infection.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...


Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error