1921
Volume 29, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The nature of resistance to a primary infection with (Peabody strain) was studied in lethally irradiated, bone marrow- and/or thymocyte-reconstituted BALB/c mice. Mice depleted of T lymphocytes by thymectomy, lethal irradiation, and reconstitution with anti-theta serum-treated bone marrow cells developed significantly higher parasitemias than sham-thymectomized, lethally irradiated mice reconstituted with thymocytes alone. Natural resistance to could be partially restored to T lymphocyte-depleted mice by transfer of spleen cells depleted of B lymphocytes by treatment with anti-immunoglobulin serum. The greatest resistance to infection among lethally irradiated mice, however, was observed when T lymphocytes were given to mice with intact thymuses. The return of the spleen to normal size after enlargement resulting from infection with was shown to be a T cell-mediated response. Twenty days after peak parasitemia, the total cell and leucocyte numbers in the spleens of mice depleted of T lymphocytes were considerably higher than those of mice given T cells. A depression of humoral immune responsiveness to sheep red blood cells was also noted during primary infection, while cell-mediated immune responses remained near normal. Although the mechanism of parasite destruction was not determined, these results suggest that resistance to and recovery from a primary infection is modulated by T lymphocytes, and that depressed B cell function and normal T cell function are correlates of this infection.

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/content/journals/10.4269/ajtmh.1980.29.507
1980-07-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1980.29.507
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  • Accepted : 02 Feb 1980

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