Volume 29, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Of 21 confirmed cases of New World leishmaniasis, 16 exhibited antibody to antigens of the promastigote of by the enzyme-linked immunosorbent assay (ELISA). Comparison of antibody titers obtained by ELISA with titers obtained by indirect immunofluorescence using an amastigote substrate confirmed that the sensitivities of the two techniques were within the same range (r = 0.80). Although sera from patients with New World leishmaniasis failed to react with antigens extracted from epimastigotes of , sera from 39 cases of Chagas' disease were reactive with promastigotes of . This apparent unidirectional cross-reactivity has been attributed to differences in potency of the antigenic stimulus presented in the two diseases.


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