Volume 28, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Impairment of cell-mediated immunity has been described in chemically-induced as well as mutation diabetes in the mouse. The present report examines the host-parasite relationship during the acute phase of schistosomiasis mansoni in the mutation diabetic mouse (db/db). Cercarial penetration and maturation and egg output by adult worms were similar in the db/db mice and their littermate controls (db/+). In contrast, the pathological consequences of schistosomiasis were much less in the db/db mice. The mean liver weight computed as a percentage of body weight in db/db mice was 4.6 ± 0.2 and following 8 weeks of infection it was 5.7 ± 0.3 (difference is not statistically significant), whereas in infected db/+ mice it was 7.2 ± 0.5. Infection in db/+ mice increased their mean portal pressure by 124% in contrast to an increase of only 12% in db/db animals. The most striking difference was noted in the mean granuloma diameter in the liver: 402 ± 35 µm in db/+ in comparison to 147 ± 10 µm in db/db mice ( < 0.001). This study demonstrates the crucial role of the host granulomatous response in the causation of disease due to . Furthermore, it underlines the decreased pathological consequences when the host granulomatous response is suppressed, which can be compared to the response of modulated animals with chronic schistosomiasis.


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