Volume 28, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Groups of bats () were infected by the intranasal instillation of a suspension of mycelia and spore particles of containing either 10 or 10 viable units. Bats infected with the high dose had viable in the lungs, liver, spleen and gut as early as 2 weeks post-infection. Complement-fixing antibodies to the organism were detectable 3 weeks after infection, whereas precipitating antibodies were not present until 5 weeks. Significant delayed hypersensitivity to histoplasmin was noted at 2 and 4 weeks after infection. By 9 weeks, delayed hypersensitivity had waned, while antibodies could still be demonstrated. The observation that bats are susceptible to respiratory infection with suggests a mechanism by which the disease may be maintained within a colony. Delayed hypersensitivity appears to be a sensitive, but transient, indicator of active histoplasmosis in bats.


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