Volume 27, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



To test the hypothesis that the Duffy blood group negative genotype is a factor in resistance to , we determined the Duffy blood group, the malaria antibodies, and the slide-demonstrated infection rates with and of 420 persons living in Nueva Armenia, Honduras. In all, 247 persons were Duffy negative. Demonstrated infections with were almost equally distributed between Duffy-positive (5.8%) and Duffy-negative (4.9%) persons. Similarly, Duffy-positive (25.6%) and Duffy-negative (28.2%) persons had equal proportions of indirect fluorescent antibody test titers suggestive of past or present infection. In contrast, all 14 infections were found in Duffy-positive persons. There was no evidence suggesting that Duffy-positive and Duffy-negative persons had different exposures to malaria. The Duffy negative genotype appears to be a factor in resistance to .


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