1921
Volume 27, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Eighty-nine Neotropical bats of five species were inoculated subcutaneously with epizootic or enzootic strains of Venezuelan encephalitis (VE) virus. Viremia was detected in 92.5% of all bats, but no illness attributable to virus infection was observed. Detectable viremias averaged slightly over 4 days in and , and 2.8 days in , and maximal viremia titers in these three species averaged 6.9, 6.6, and 4.6 log SMicLD per ml of blood, respectively. In general developed and maintained detectable levels of both hemagglutination-inhibition (HI) and neutralizing antibody for as long as tested (up to 506 days), although HI antibody to enzootic VE virus strains disappeared in some . The detectable antibody response of was slower and of lower magnitude and shorter duration than that of , although individual which had lost detectable HI and N antibody resisted challenge. Vertical passage of antibody was observed in three offspring. were found to be only slightly less susceptible to VE virus infection than a U.S. subspecies of the cotton rat (). No virus was recovered by mouse inoculation of organ pools of bats killed as early as 2 days and as late as 299 days after the last day of detectable viremia.

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/content/journals/10.4269/ajtmh.1978.27.297
1978-03-01
2017-09-23
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1978.27.297
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  • Accepted : 23 Jul 1977

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