1921
Volume 27, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Cytotoxicity of T-lymphocytes from patients with Chagas' disease to parasitized and non-parasitized human heart cells labelled with Cr was demonstrated. The highest ratio of Cr released from the normal, non-parasitized heart cells was observed when the T-lymphocytes were collected from patients with acute Chagas' disease. The quantity of Cr released from the normal heart cells that were destroyed by T-lymphocytes collected from patients with chronic Chagas' disease was also significantly higher than the quantity of Cr released from normal heart cells incubated with lymphocytes from normal donors. The specific release of Cr from the heart cell cultures destroyed by the immune T-lymphocytes from patients with acute Chagas' disease and from patients with chronic disease was 38.1% and 25.8%, respectively, compared to the release of Cr observed in control studies. A small particle human heart cell antigen was shown to inhibit the migration of -immune peripheral blood leukocytes. These findings appear to indicate that T-lymphocytes from patients with Changas' disease are susceptible to activation by a cross-reactive heart cell antigen and suggest that an autoimmune mechanism can be established in some cases of acute Chagas' disease and can be perpetuated in the chronic phase of this disease by the continuous antigenic stimulation. Further, these experimental data indicate that the autoimmune destruction of heart cells in Chagas' disease is produced by delayed-type hypersensitivity mediated by -sensitized T-lymphocytes.

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/content/journals/10.4269/ajtmh.1978.27.1097
1978-11-01
2017-11-19
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1978.27.1097
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  • Accepted : 17 Jun 1978

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