Volume 26, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The prophylactic and therapeutic efficacies of IA-4 N-oxide against in rhesus monkeys () have been evaluated. Ten monkeys were divided into 5 groups of 2 monkeys each. All monkeys were exposed to cercariae on day 0 and treatment groups were established as follows: untreated controls, oral prophylactic administration, intramuscular prophylactic administration, oral therapeutic administration, and intramuscular therapeutic administration. Analysis of parasitologic and pathologic criteria indicate that the compound is most effective when administered as a therapeutic regimen. Complete cures were effected in these monkeys. Prophylactic treatments resulted in a delay in onset of patency and reductions in fecal egg excretion, worm burdens, and tissue damage.


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