Volume 26, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



This report summarizes the results of a comparative study of the virulence of the “,” , and strains of for Indian rhesus monkeys () and cynomolgus monkeys [] of Malayan (West Malaysia) and Philippine origins. Each of the above strains produced fulminating, uniformly fatal infections in the rhesus monkey and mild, chronic infections, characterized by relatively low level parasitemias in cynomolgus monkeys of Philippine origin. In striking contrast, the and strains produced infections in cynomolgus monkeys of Malayan origin which were indistinguishable in severity from infections produced in . The circumstances of the study precluded evaluation of the virulence of the “” strain for of Malayan origin. Even so, the available data make it necessary to qualify the long-held belief that infections with in invariably follow a benign course.


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