1921
Volume 26, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The effects of 3-methyl-4-(5′-nitrofurfurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide [Lampit, Bayer 2502] on the intracellular cycle of were studied with an in vitro steady-state culture system that permitted the continuous analysis of individual host cell-parasite interactions. Lampit concentrations of 10 and 10 M significantly affected the ability of trypomastigotes to penetrate vertebrate cells. Lampit concentrations above 10 M were toxic to the host cell population and Lampit concentrations below 10 M did not affect the ability of trypomastigotes to penetrate vertebrate cells. Lampit concentrations of 10 M or greater completely inhibited the intracellular cycle of whereas Lampit concentrations of 10 M or less had no effect on the intracellular cycle. Continuous perfusion with 10 M Lampit resulted in a linear increase in intracellular parasite reproduction time. A stable strain of was produced in vitro that was resistant to a 100-fold greater concentration of Lampit than the parent strain.

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/content/journals/10.4269/ajtmh.1977.26.58
1977-01-01
2017-09-20
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1977.26.58
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  • Accepted : 22 May 1976

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