Volume 26, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Complement dependent cytotoxic antibodies for schistosomules were studied in a Brazilian population. The sera of -infected patients gave a high percentage of cytotoxicity (63.4%) compared with sera from persons not infected (8.7%). The IgG class and the specificity of these cytotoxic antibodies are defined. The index of lethality appeared to be independent of the titers of other specific anti- antibodies. A statistical correlation was found between the index of lethality and both the severity of the disease and delayed hypersensitivity to antigen. The significance of cytotoxic antibodies in human schistosomiasis and their relevance to immunity in man are discussed.


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