Immunology of Parasitic Infections: Report of a Workshop
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The clinical pattern of acquired immunity to malaria varies widely in different parasite host species. In some instances there is no effective immune response and the disease is rapidly fatal, e.g., in the rhesus monkey. More commonly, however, induced immunity controls but does not eliminate the infection, which persists at low density over long periods—a sequence referred to as ‘premunition,’ e.g., in man. Finally, malaria may result in clinical cure, complete elimination of the parasite (sterilizing immunity) and life-long resistance to challenge, e.g., in the rat. A given species of does not induce comparable immunity in different hosts, e.g., produces a rapidly fatal infection in the rhesus monkey, , but mild intermittent parasitemia in the kra monkey, . In addition, immunity may be age-dependent, as in the rat where the diminishing intensity of infections is associated with altered immune responsiveness.


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