1921
Immunology of Parasitic Infections: Report of a Workshop
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Immunity to haemoprotozoa is complex, involving several components that interact in ways that vary from one host-parasite combination to another. In recent years, most attention has been given to antibody formation, which is relatively easily measured. It has been suggested that antibodies interfere with the penetration of merozoites into erythrocytes, or opsonize parasites or parasitized erythrocytes for phagocytosis by macrophages. Our observations on human and rodent malaria and infections show that other factors must also be borne in mind.

Erythrocytes themselves differ in susceptibility to infection, and some of the factors underlying these differences are known, as will shortly be summarized. These differences are specific for each parasite, even though they do not depend upon acquired responses of immunocompetent cells.

That both T- and B-lymphocytes respond to parasite antigens is, nevertheless, clear. Cells of the B-lymphocyte lineage produce antibodies to the parasites, and ways of detecting responses to T-lymphocytes are considered later.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1977.26.216
1977-11-01
2017-09-26
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1977.26.216
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error